Report of Pharmacological Profile and Safety/Toxicity of Yograj Guggulu and Mahanarayana Taila (Classical Formulations)

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Ayurveda literally meaning the science of life is a comprehensive system of health care great antiquity, based on experimental knowledge and soen with compendia of Indian wisdom called Vedas, which are believed to be cocumented around 6000 years back. Rigveda and Atharvaveda are replete with information on health and maladies and their management with natural modes and codalities. The knowledge expanded with laying down of fundamentals and concepts of Ayurveda and systematization in classical texts like Charaka Samhita, Sushruta Samhita and Ashtanga Sangraha. Present form of Ayurveda is the outcome of continued scientific inputs that has gone into the evolution of its principles, theories and guidelines of healthy living and disease management. Considering health of an individual as dynamic integration of environment, body, mind and spirit, Ayurveda lays great emphasis on preservation and promotion of health and preventing the occurrence of disease. besides, it advocates holistic approach to understand all aspects of human life including diagnosis and management of disease.

In the current scenario use of Ayurveda has expanded globally and is continued to be used for primary health care of the poor in India and in certain other developing countries where conventional medicine is predominjant in the national health care system. With the growing use of Ayurveda and its pharmaceutical sector, the safety and efficacy as well as quality control concerns of both regulatory authorities and the public are being addressed systematically. Standard operating procedures (SOPs) and Pharmaceutical standards have been evolved for Ayurvedic drugs to prevent batch to batch quality variation. Apart from GMP requirements, necessary regulations are in place to encure the quality of products. The products should pass the physicochemical quality control parameters and also limits for microbial load, heavy metal content, pesticide residue and aflatoxins.

Sandhigatavata (Osteo-arthritis)is one among the chronic and degenerative diseases has become a challenge to the detailed description authorities and public. The de- tailed description concerning aetiology, clinical teatures and line of management are available in ancient and medicinal classics of Ayurveda. Ayurveda attributes factors such as improper and irregular diet preactices (Viruddha Ahara), impaired gastrointestinal functions (Mandagni), repeated trauma etc. as pivotal factors result- ing in the degenerative changes in this condition.

Ayurveda offers a comprehensive, safe and effective approach to the management of Sandhigatavata (osteo-arthritis). The contemporary approach of management comprising of NSAIDS etc. cause certain adverse events like gastric irritation, gastric ulcers etc. leading to considerable amount of discomfort.

Considering this Council has initiated the preclinical studies of Yogaraj Guggulu and Mahanarayana taila in albino rats/mice at our councils centre. This monograph contains standard manufacturing procedure including standardization, biological activity and safety studies of Yogaraj Guggulu and Mahanarayana taila in lab animals. I appreciate the efforts of Dr. Sudesh Gaidhani, Asst. Director (Pharmacology), Dr. M.M. Padhi, Deputy Director (T), Shri Arjun Singh, Research Officer (Chemistry), Dr. B.S. Sharma, Research Officer (Ayurveda) and Miss Suman Kumari, SRF (Chemistry) in bringing out this monograph.

I hope that this monograph will help students, practitioners, academicians, research scholars, scientists and certainly help in catering better health care services.

**Contents and Sample Pages**